HIV-1 protease inhibitors are drugs that target HIV-1 proteases, which are required for viral replication. Despite the success of protease inhibitors for suppressing HIV-1, some patients do not respond to protease inhibitor therapy. For most patients, the lack of response is not due to mutation of the HIV-1 protease. In this issue of the iJournal of Clinical Investigation/i, Robert Silcano and colleagues at Johns Hopkins University identify the effects ...
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