Mainly in older patients with comorbidities, use of bioprosthetic heart valves has dramatically increased (from 18% in 1991 to 59% in 2003). This is due to the increased risk of bleeding complications associated with lifelong use of anticoagulation for mechanical prostheses. But structural valve deterioration is one the main complications associated with bioprosthetic heart valves. In large registries including more than 300 000 patients undergoing ...
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