Blocking the action of a signalling molecule in the immune system could prevent insulin resistance and inflammation associated with obesity, a new study found. Reporting in this week's issue of iNature Medicine/i, the NYU Langone team showed in experiments in mice and human tissue that Netrin-1 signaling is propelled by fat tissue growth. The team previously discovered that Netrin-1 was secreted by the immune system clean-up cells, or macrophages, whose buildup ...
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