Plasminogen activators are proteins involved in the breakdown of blood clots. And an elevated level of plasminogen activator inhibitor-1 (PAI-1) is associated with an increased risk for cardiovascular disease and clotting. No PAI-1 inhibitors are currently available for clinical use, but a novel therapeutic approach using a targeted RNA aptamer drug that has been shown to block PAI-1 activity and prevent PAI-1-associated vascular events is described in emNucleic ...
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