
Specific areas of the brain that regulate metabolism can be manipulated with a protein that controls when genes are switched on or off, UT Southwestern Medical Center researchers have found. The research potentially could lead to new therapies to treat obesity and diabetes, since the transcription factor involved - spliced X-box binding protein 1 (Xbp1s) - appears to influence the body's sensitivity to insulin and leptin signaling. Insulin and leptin are hormones ...
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