A research team have pinpointed a surprising mechanism behind neurodegeneration in mice, one that involves a defect in a key component of the cellular machinery that makes proteins, known as transfer RNA or tRNA. The research team was led by Jackson Laboratory Professor and Howard Hughes Investigator Susan Ackerman, Ph.D. The researchers report in the journal emScience/em that a mutation in a gene that produces tRNAs operating only in the central nervous system ...
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