Apoptosis of Hippocampal Neurons may be Mediated by Toll-Like Receptor 4

Scientists have always been puzzled about the turnover of neurons in the hippocampal region of the brain. Toll-like receptor 4 (TLR4) antibody, protein kinase B (AKT) inhibitor, LY 294002, and glycogen synthase kinase 3 (and) #946; (GSK-3 (and) #946;) inhibitor, LiCl, were used by Yu He and colleagues from Nantong University, China to attenuate or augment the effects of the TLR4-phosphatidylinositol 3 kinase (PI3K)/AKT-GSK-3 (and) #946; signaling pathway so as to identify the participation ...

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Written by: editor - Sunday, December 8, 2013

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