Enhancers Control Potentially Dangerous Hypermutation to Antibody Genes

For decades, biologists were fascinated as how B lymphocytes are able to direct mutations to their antibody genes to produce millions of different antibodies. A new study publishing in the Open Access journal iPLOS Biology/i on April 1 by Buerstedde and colleagues shows that this process of programed, spatially targeted genome mutation (aka. somatic hypermutation) is controlled by nearby transcription regulatory sequences called enhancers. Enhancers are usually ...

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Written by: editor - Wednesday, April 2, 2014

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