Previous research has shown that while doxorubicin is a widely used as a component of chemotherapy regimes; it's use is associated with severe cardiotoxicity. It is unclear exactly how doxorubicin promotes cardiotoxicity, but it has been proposed that doxorubicin-associated cardiomyopathy develops as the result of reactive oxygen species (ROS) production and iron accumulation. In this issue of the iJournal of Clinical Investigation/i, Hossein Ardehali ...
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titled Doxorubicin-Associated Cardiotoxicity Promoted by Mitochondrial Iron Accumulation.
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editor - Friday, January 3, 2014
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